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. 2022 Apr 6;298(5):101904. doi: 10.1016/j.jbc.2022.101904

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Glibenclamide and carbamazepine (Carb) increase mature SUR1 in cells expressing mutant K_ATPchannels.A, top, representative images show the effects of Glib on SUR1 in HEK293 cells expressing WT (SUR1/Kir6.2) or mutant (SUR1/Kir6.2-A28V) K_ATP channels. Bottom, quantification of the upper (mature) and lower bands of SUR1 is shown in the left and right plots, respectively. B, top, representative images show the effects of Carb on SUR1 in HEK293 cells expressing WT or mutant K_ATP channels. Bottom, quantification of the upper (mature) and lower bands of SUR1 is shown in the left and right plots, respectively. Data are presented as the mean ± SEM; n = 8 per group; ∗p < 0.05, compared with DMSO-treated cells in each corresponding group; differences were evaluated using two-way ANOVA and Dunnett's post hoc test. DMSO, dimethyl sulfoxide; HEK293, human embryonic kidney 293 cell line; K_ATP, ATP-sensitive potassium channel; SUR1, sulfonylurea receptor 1.