Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 6;298(5):101904. doi: 10.1016/j.jbc.2022.101904

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Carbamazepine (Carb) decreases the colocalization of mutant K_ATPchannels with lysosomes.A, representative immunostaining images show the distribution of HA (green) and LAMP1 (red) in INS-1 cells expressing WT (HA-SUR1/Kir6.2) or mutant (HA-SUR1/Kir6.2-A28V) K_ATP channels, upon 10 μM Carb treatment for 16 h. B, the bar graph shows the mean fluorescence intensity for colocalization of HA and GM130. Data are presented as the mean ± SEM; n = 4 per group; ∗∗∗p < 0.005 compared with the DMSO-treated cells in each corresponding group; differences were evaluated using two-way ANOVA and Dunnett's post hoc test. The scale bar represents 10 μm. DMSO, dimethyl sulfoxide; HA, hemagglutinin; K_ATP, ATP-sensitive potassium channel; LAMP1, lysosomal-associated membrane protein 1; SUR1, sulfonylurea receptor 1.