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. 2022 Apr 26;8(4):e09288. doi: 10.1016/j.heliyon.2022.e09288
Model Parameters
Parameter Value Description
ω 0.19 Decay Rate of Immunogenic Dendritic Cells [25]
ωI 0.35 Decay Rate of Immature Dendritic Cells [25]
ωT 0.456 Decay Rate of Tolerogenic Dendritic Cells [25]
ωC 1.2 ⋅ 10−1 Decay Rate of Cytotoxic T-Cells [49]
ωN 1.12 ⋅ 10−2 Decay Rate of Naive T-Cells
ωR 2.34 ⋅ 10−2 Decay Rate of Regulatory T-Cells
ω2 23 Decay Rate of IL-2 [48]
ω10 123 Decay Rate of IL-10
ωCH 3.45 ⋅ 102 Decay Rate of Chemotherapy Medicine
kC 0.086 The relative size of tumor needed for half-maximal stimulation of Cytotoxic T-cells
c .018 Max Growth Rate of T-regs [47]
aT 1.236 Activation Rate of Tolerogenic Dendritic Cells by Tregs
dCP 60 Deactivation Rate of Cytotoxic Analysis T-Cells by Tregs [34]
d 67 Deactivation Rate of Cytotoxic T-Cells by Dendritic Cells [49]
α2 0.021 Source Rate of IL-2 [47]
α10 0.34 Source Rate of IL-10 from Dendritic Cells [34]
αN 1.232 Source Rate of Naive T-cells
aCP 0.465 Activation Rate of Cytotoxic Cells by IL-2
gR .018 Max Growth Rate of Tregs [47]
aR 6.984 Activation Rate of Tregs
g2 12 Growth Rate of Cytotoxic T-Cells
g10 56 Deactivation Rate of Cytotoxic T-Cells by Tregs
aC 0.768 Activation Rate of Naive T-Cells by Dendritic Cells [34]
kDI 3.848 The relative size of tumor needed for half-maximal stimulation of Immature dendritic cells
a 2.223 Activation Rate of Immature dendritic cells
kDT 87.646 The relative size of tumor needed for half-maximal stimulation of Tolerogenic dendritic cells
kN 0.0634 The relative size of tumor needed for half-maximal stimulation of Naive T-cells
a10 2.976 Activation Rate of Regulatory T-cells
a2 3.9578 Activation Rate of Cytotoxic T-cells by Interleukin 2 (IL-2)
δ() ∈[0.32 ⋅ 10−2,2.879 ⋅ 10−1] Pure coefficient in exponential expression
kR 321 Level of Tregs necessary for half maximal activation of tolerogenic dendritic cells
bT 0.45 Activation Rate of Tolerogenic Dendritic Cells by IL-10
γ 12 Growth Rate of Cytotoxic T-Cells [49]
a10 0.453 Source Rate of IL-10 from Tregs