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. 2019 Jul 1;9(35):20439–20449. doi: 10.1039/c9ra03279g

Response surface central composite design (CCD) and their experimental results.

Run Actual values Coded values Response
X 1 X 2 X 3 X 4 X 1 X 2 X 3 X 4 Actual Predicted
1 20 8 0.2 30 0 0 0 −1 85.60 87.93
2 10 11 0.1 30 −1 +1 −1 −1 66.30 63.90
3 10 5 0.3 90 −1 −1 +1 +1 67.90 69.46
4 20 8 0.3 60 0 0 +1 0 88.70 86.90
5 20 11 0.2 60 0 +1 0 0 65.30 67.12
6 30 5 0.1 90 +1 −1 −1 +1 66.20 64.70
7 30 11 0.1 30 +1 +1 −1 −1 63.40 61.86
8 30 11 0.3 30 +1 +1 +1 −1 60.30 60.64
9 10 5 0.1 90 −1 −1 −1 +1 66.80 66.44
10 30 11 0.1 90 +1 +1 −1 +1 59.80 60.72
11 10 11 0.3 30 −1 +1 +1 −1 60.40 61.92
12 10 8 0.2 60 −1 0 0 0 92.80 92.26
13 10 11 0.3 90 −1 +1 +1 +1 62.90 61.93
14 10 5 0.3 30 −1 −1 +1 −1 68.20 67.25
15 30 5 0.3 30 +1 −1 +1 −1 65.90 64.72
16 30 5 0.3 90 +1 −1 +1 +1 66.10 68.48
17 10 5 0.1 30 −1 −1 −1 −1 66.00 66.93
18 20 8 0.1 60 0 0 −1 0 84.20 86.00
19 20 5 0.2 60 0 −1 0 0 73.60 71.78
20 30 5 0.1 30 +1 −1 −1 −1 62.70 63.64
21 10 11 0.1 90 −1 +1 −1 +1 60.00 61.21
22 20 8 0.2 90 0 0 0 +1 90.80 88.47
23 30 8 0.2 60 +1 0 0 0 90.20 90.74
24 30 11 0.3 90 +1 +1 +1 +1 63.10 62.20