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. 2019 Jul 2;9(36):20573–20581. doi: 10.1039/c9ra02763g

Study of the influence of different solvents (20 mL) on the reactions between 6-chloro-3-formylchromone (1 mmol), 2-amino-6-methoxybenzothiazole (1 mmol) and alcohols (2 mmol).

Entry Alcohol Solvent Time Product Yield (%)
1 n-Butanol DCM 12 h a
2 n-Butanol THF 4 h 4f 94
3 n-Butanol DMF 12 h b
4 n-Butanol CH3CN 12 h b
6 1-Octanol DCMb 10 h 3bic 10
7 1-Octanol DMF 12 h b
8 1-Octanol DMSO 12 h b
9 1-Octanol Xylene 12 h b
a

Difficult to purify.

b

Decomposed.

c

Purified by column chromatography.