VINB/TV-AE actions on gastrointestinal motility in healthy and intoxicated ratsa.
| Group | Dose | Gastro-intestinal motility (%) | Reduction activity (%) | Reinforcement (%) |
|---|---|---|---|---|
| Control (NaCl) | (5 mL kg−1) | 70.65 ± 3.63 | — | — |
| Clonidine | (1 mg kg−1) | 28.23 ± 1.77* | 60.04 | — |
| VINB | (2 mg kg−1) | 65.12 ± 1.66* | 07.82 | — |
| TV-AE alone | (100 mg kg−1) | 77.92 ± 3.45*# | — | 10.29 |
| (200 mg kg−1) | 83.74 ± 2.88*# | — | 18.52 | |
| VINB/TV-AE | (100 mg kg−1) | 68.90 ± 2.18# | — | 5.80 |
| (200 mg kg−1) | 71.33 ± 3.46# | — | 09.53 |
a
Rats were intoxicated with VINB (2 mg kg−1) for one week. Then, the animals were treated with two increasing doses of TV-AE or reference molecule (clonidine, 1 mg kg−1). 2 h later, the rats were given the standard charcoal meal (10% charcoal in 5% gum arabic) or vehicle (NaCl, 0.9%). Data are expressed as mean ± standard error (n = 7); *P < 0.05 versus control group, #P < 0.05 versus VINB-group.