Identification of parameters following acute drug disorders and TV-AE effectsa.
| Rat group | Fecal parameters on day 5 (collection for 24 h) | Gastric mucosa injury indicators | |||||
|---|---|---|---|---|---|---|---|
| Fecal pellet (n) | Wet weight (g/24 h/rat) | Dry weight (g/24 h/rat) | Water content (%) | Ulcer index | Gastric juice volume (mL) | Gastric juice pH | |
| CONT (NaCl) | 56.23 ± 3.00 | 6.77 ± 4.64 | 3.21 ± 0.33 | 39.08 ± 3.10 | 0.23 ± 0.04 | 2.04 ± 0.14 | 3.46 ± 0.09 |
| VINB (2 mg kg−1) | 48.64 ± 3.21* | 4.23 ± 0.21* | 2.22 ± 0.70* | 27.66 ± 2.63* | — | — | — |
| INDO (30 mg kg−1) | — | — | — | — | 19.77 ± 1.56 | 4.44 ± 0.16 | 2.31 ± 0.06 |
| TV-AE (100 mg kg−1) | 51.11 ± 2.90* | 4.93 ± 0.55* | 2.97 ± 0.61* | 31.17 ± 3.55* | 10.64 ± 1.20* | 2.62 ± 0.37*# | 2.87 ± 0.12*# |
| TV-AE (200 mg kg−1) | 55.50 ± 1.72# | 5.64 ± 0.81# | 3.24 ± 0.10# | 37.44 ± 2.85# | 3.00 ± 0.06* | 2.12 ± 0.22# | 3.72 ± 0.10# |
a
VINB/INDO alterations reflected by indicated parameters and assessed in healthy rats and rats treated with VINB (2 mg kg−1) or INDO (30 mg kg−1). Data are expressed as mean ± standard error (n = 7); *P < 0.05 versus control group, #P < 0.05 versus VINB/INDO groups.