VINB/INDO/TV-AE actions on intracellular mediator disturbances in healthy and treated ratsa.
| Group | Dose | H2O2 (μmol mg−1 protein) | Free iron (nmol mg−1 protein) | Calcium (10−3 nmol mg−1 protein) |
|---|---|---|---|---|
| CONT (NaCl) | (5 mL kg−1) | 09.05 ± 0.33 | 11.34 ± 0.06 | 33.67 ± 3.57 |
| VINB | (2 mg kg−1) | 25.77 ± 2.13* | 7.04 ± 0.17* | 19.47 ± 2.07* |
| VINB/TV-AE | (100 mg kg−1) | 24.70 ± 2.11*# | 9.24 ± 0.21 | 22.99 ± 0.84* |
| (200 mg kg−1) | 11.98 ± 1.22# | 10.24 ± 0.06# | 28.90 ± 1.34# | |
| INDO | (30 mg kg−1) | 37.33 ± 2.29* | 04.28 ± 0.07* | 21.38 ± 1.01* |
| INDO/TV-AE | (100 mg kg−1) | 19.15 ± 1.37*# | 07.52 ± 0.20*# | 27.10 ± 0.74# |
| (200 mg kg−1) | 12.65 ± 0.93# | 09.35 ± 0.13# | 30.80 ± 2.21# |
a
VINB/INDO/TV-AE effects were reflected by intracellular mediators assessed in healthy rats and rats treated with VINB (2 mg kg−1) or INDO (30 mg kg−1). Results are expressed as mean ± SEM; n = 7 in each group. Data was analyzed by Statview ANOVA. Data are expressed as mean ± standard error (n = 7); *P < 0.05 versus control group, #P < 0.05 versus VINB/INDO-groups.