Fig. 3. Dynamic stability of mature PS2-γ-secretase during three 500 ns MD simulations in the membrane. (A) The root-mean squared deviation (RMSD) of the backbone atoms of PS2-γ-secretase. (B) The compactness of the trajectories estimated by the mean of radius of gyration (Rg) over 500 ns time. (C) The solvent accessible surface area (SASA) of the three PS2-γ-secretase systems. (D) The minimum Cα-distance of the catalytic Asp-263 and Asp-366. Black lines represent simulation 1, red lines represent simulation 2, and green represents simulation 3.
