Fig. 6. Free energy landscapes of the three simulations of PS2-γ-secretase and PS2 alone in the membrane as a function PC1 and PC2. The colored scale to the right defines the relative free energy, with dark blue being deep minima. (A) FEL profile of complete PS2-γ-secretase obtained from Simulation 1. (B) FEL profile of PS2-γ-secretase obtained from Simulation 2. (C) FEL profile of PS2-γ-secretase obtained from Simulation 3. (D) FEL profile of the PS2 subunit extracted from the full complex from Simulation 1. (E) FEL profile of PS2 from Simulation 2. (F) FEL profile of PS2 from Simulation 3.
