TABLE 4.
Adjusted hazard ratios for adverse cardiac events associated with LVDDF groups as defined by the 2016 ASE/EACVI recommendations or population‐derived age‐specific criteria
| Fatal and non‐fatal cardiac events | Fatal and non‐fatal HF and AF events | ||||||
|---|---|---|---|---|---|---|---|
| Algorithm | Total N | N of events | HR (95% Cl) | P value | N of events | HR (95% Cl) | P value |
| ASE/EACVI 2016 | |||||||
| Normal LV diastolic function | 996 | 33 | Reference | / | 10 | Reference | / |
| Indeterminate | 109 | 20 | 1.07 (0.91 to 1.25) | 0.41 | 10 | 1.16 (0.91 to 1.48) | 0.23 |
| Grade 1 LVDDF | 276 | 41 | 1.17 (0.89 to 1.54) | 0.25 | 23 | 1.48 (0.96 to 2.28) | 0.075 |
| Grade 2 LVDDF | 26 | 6 | 1.20 (0.86 to 1.66) | 0.28 | 4 | 1.35 (0.86 to 2.13) | 0.19 |
| Population age‐specific criteria | |||||||
| Normal LV diastolic function | 1028 | 36 | Reference | / | 13 | Reference | / |
| Low risk LVDDF | 127 | 8 | 1.13 (0.76 to 1.68) | 0.53 | 4 | 1.18 (0.66 to 2.10) | 0.58 |
| High risk LVDDF | 252 | 56 | 1.28 (1.08 to 1.51) | 0.0045 | 30 | 1.50 (1.00 to 1.69) | 0.047 |
CI, confidence interval; LV, left ventricular; LVDDF, LV diastolic dysfunction.
Hazard ratios (HRs) express the adjusted risk in each group of LVDDF at baseline compared with the risk in the subjects with normal LVDF. All HRs were adjusted for sex, age, body mass index, systolic blood pressure, serum cholesterol, smoking, diabetes mellitus, history of cardiac disease, and left ventricular mass index.