Table 3.
Original studies referred to in relation to suspicion criteria in the form of symptoms and diagnoses
| Suspicion criteria | Study type | |||
|---|---|---|---|---|
| Prospective | Retrospective | Autopsy | Registry | |
| HFpEF |
ATTRwt CM in 13% of patients admitted with HFpEF and vwt ≥ 12 mm 1 ATTRwt CM in 18% of patients >65 years with HFpEF 58 ATTRwt CM in 6% of patients with HFpEF as evaluated by myocardial biopsy analysis 59 |
Broad description of ejection fraction in patients with ATTRwt CM 60 | 5% of patients with HFpEF had ATTRwt CM as the primary reason for HFpEF 61 | |
| Carpal tunnel syndrome |
TTR amyloid in tenosynovial tissue from patients undergoing CTS surgery was found in 34% (no check for amyloid in the heart) 62 TTR amyloid in tenosynovial tissue from patients undergoing CTS surgery was found in 10.2% (cardiac involvement confirmed in one patient) 63 Confirmed ATTRwt CM was reported in 0.85% of patients undergoing CTS surgery 64 |
CTS prevalence of 20–60% reported in patients with ATTRwt CM 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 | Risk of ATTRwt CM 12× increased in patients undergoing CTS surgery 75 | |
| Lumbar spinal stenosis |
TTR amyloid found in 33% of LSS surgery samples, no check for cardiac symptoms 76 TTR amyloid found in 45% of LSS surgery samples, no cardiac symptoms found 77 |
14% of patients with ATTRwt CM had a history of LSS 67 | ||
| Neuropathy |
Of ATTRwt CM patients, 12% had neuropathic pain, 12% had numbness, and 13% had tingling CM 65 , 78 12% of patients with ATTRwt MS had autonomic neuropathy manifesting as orthostasis 70 |
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| Atrial fibrillation | Atrial fibrillation was reported in 27–67% patients with ATTRwt CM 3 , 60 , 66 , 70 , 79 , 80 | |||
| Aortic stenosis |
ATTRwt CM was reported in 6% of patients undergoing SAVR 81 ATTRwt CM was reported in 12–16% in patients undergoing TAVR 82 , 83 , 84 ATTRwt CM was reported in 12% of patients undergoing SAVR or TAVR 85 |
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ATTRwt CM, wild‐type transthyretin amyloid cardiomyopathy; CTS, carpal tunnel syndrome; HFpEF, heart failure with preserved ejection fraction; LSS, lumbar spinal stenosis; SAVR, surgical aortic valve replacement; TAVR, transcatheter aortic valve replacement; TTR, transthyretin.