Table 1.
Differential Nuclear Receptor Expression in Carcinomatous versus Sarcomatous Components of Gynecologic Carcinosarcomas.
| GR H-score | ER H-score | PR H-score | AR H-score | ||
|---|---|---|---|---|---|
| Overall (n = 18) | Sarcomatous - mean (range) |
144.4 (0–300) |
3.1 (0–50) |
1.7 (0–20) |
0 (0–0) |
| Carcinomatous - mean (range) |
38.9 (0–160) |
63.1 (0–300) |
47.2 (0–210) |
2.8 (0–20) |
|
| Mean of differences (range) |
105.6 (-70–300) |
−60 (-270–5) |
−45.6 (-210–0) |
−2.8 (-20–0) |
|
| 95% Confidence Interval | 47.3–163.8 | −107.4 to −12.6 | −74.7 to −16.5 | −5.6 to 0.1 | |
| P-value | 0.002 | 0.002 | <0.0001 | 0.04 | |
| Ovarian (n = 10) | Sarcomatous - mean (range) |
185 (10–300) |
0.5 (0–50) |
3 (0–20) |
0 (0–0) |
| Carcinomatous - mean (range) |
68 (10–160) |
96.5 (0–300) |
63 (0–210) |
4 (0–20) |
|
| Mean of differences (range) |
117 (-70–290) |
−91.5 (-270–0) |
−60 (-210–0) |
−4 (-20–0) |
|
| 95% Confidence Interval | 29.5 to 204.5 | −173.9 to −9.1 | −111.9 to −8.1 | −9.0 to 1.0 | |
| P-value | 0.01 | 0.008 | 0.007 | 0.08 | |
| Uterine (n = 8) | Sarcomatous - mean (range) |
93.8 (0–300) |
0.6 (0–5) |
0 (0–0) |
0 (0–0) |
| Carcinomatous - mean (range) |
2.5 (0–20) |
21.3 (0–120) |
27.5 (0–90) |
1.3 (0–10) |
|
| Mean of differences (range) |
91.3 (0–300) |
−20.6 (-40–5) |
−27.5 (-90–0) |
−1.3 (-10–0) |
|
| 95% Confidence Interval | −6.5 to 189 | −56.2 to 15.0 | −52.3 to −2.7 | −4.2 to 1.7 | |
| P-value | 0.005 | 0.11 | 0.005 | 0.38 |
Legend:
GR = glucocorticoid receptor; ER = estrogen receptor; PR = progesterone receptor; AR = androgen receptor.
p-value: computed using t-tests.
H-score was calculated by multiplying staining intensity (0 to 3 + ) by percentage of cells (0 to 100%) with staining.