Table 1.
Effects of oral administration Effects of pre and concurrent oral administration of thymol (100 or 200 mg/kg BW) on serum level of ALT, AST, ALP, creatinine, urea, TNFα and MPO of Acetylsalicylic acid-treated rats.
| Group |
Parameters |
||||||
|---|---|---|---|---|---|---|---|
| ALT (U/L) | AST (U/L) | ALP (IU/L) | Creatinine (mg/dl) | Urea(mg/dl) | TNFα (pg/ml) | MPO (ng/ml) | |
| Control | 18.74 ± 0.16d | 24.1 ± 0.31d | 33.46 ± 0.1d | 0.86 ± 0.01c | 21.06 ± 0.3d | 43.2 ± 0.6c | 9.07 ± 0.1c |
| Th100 | 18.66 ± 0.44d | 23.66 ± 0.1d | 33.8 ± 0.1d | 0.85 ± 0.01c | 21.80 ± 0.5d | 42.6 ± 0.6c | 9.22 ± 0.1c |
| Th200 | 18.61 ± 0.42d | 24.1 ± 0.13d | 33.8 ± 0.1d | 0.87 ± 0.01c | 20.9 ± 0.4d | 42.5 ± 0.8c | 9.55 ± 0.1c |
| ASA | 66.40 ± 0.22a | 95.58 ± 1.1a | 104.6 ± 1.6 a | 2.67 ± 0.04 a | 83.20 ± 1.1a | 176.4 ± 1.4a | 31.2 ± 0.2a |
| Th100 + ASA | 41.11 ± 0.33b | 42.24 ± 0.2b | 48.46 ± 0.3b | 1.78 ± 0.01b | 46.40 ± 0.5b | 56.6 ± 0.6b | 15.5 ± 0.1b |
| Th200 + ASA | 36.54 ± 1.2c | 35.94 ± 0.1c | 42.7 ± 0.4c | 1.62 ± 0.01b | 42.28 ± 0.3c | 55.4 ± 0.7b | 15.8 ± 0.1b |
Values are represented as the mean ± SE (n = 5). Mean values for the same parameter carrying different superscripts (a, b, c) are significantly different at p < 0.05. ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; TNFα: tumor necrosis factor-alpha; MPO: myeloperoxidase.