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. 2022 Apr 29;80:104037. doi: 10.1016/j.ebiom.2022.104037

Figure 4.

Fig 4

Gene expression profiles of THP-1 cells after stimulation with different bacterial LPS. (A) Volcano plots of differential expression genes (DEGs, threshold fold change > 1.5 and FDR < 0.05) in THP-1 cells stimulated with LPS from each bacterium compared with unstimulated THP-1 cells. Red dots indicate upregulated DEGs and blue dots indicate downregulated DEGs. The horizontal and vertical dark green lines indicate fold-change (log2) thresholds and adjusted p-value (log10). (B) Heatmap of fold changes (log2) in gene expression for B. fungorum, S. marcescens, or P. myrsinacearum stimulated THP-1 cells compared to unstimulated THP-1 cells. (C) The most altered GO pathways enriched in coherently changed genes in THP-1 cells stimulated by B. fungorum or S. marcescens versus P. myrsinacearum. (D) The expression of various genes encoding products in selected pathways showing increased (red) or decreased (blue) expression in THP-1 cells treated with B. fungorum (B. f) or S. marcescens (S. m) compared to P. myrsinacearum (P. m).