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. 2022 Apr 29;80:104037. doi: 10.1016/j.ebiom.2022.104037

Figure 6.

Fig 6

B. fungorum and S. marcescens, the bacteria enriched in INRs, impaired CD4+ T cell function. 6-week-old healthy C57BL/6 mice were injected with PBS, heat-killed B. fungorum, S. marcescens, or P. myrsinacearum twice a week for eight weeks by i.p. route (n = 5 per group). The mice were sacrificed on day three after the last injection (day 1). (A) The percentage of apoptotic cells and dead cells in the mesenteric lymph nodes. One-way ANOVA followed by Tukey's post hoc test, *p < 0.05, **p < 0.01. (B, C) The portion of functional memory CD4+ T cells (B) and functional naïve CD4+ T cells (C) from spleen. The spleen CD4+ T cells were stimulated using a leukocyte activation cocktail after 18 h and measured cytokine production using flow cytometry. One-way ANOVA followed by Dunnett's multiple comparisons test. *p < 0.05, #p < 0.01.