| Quercetin (Q), kaempferol (K) and taxifolin (T) |
Anti-inflammatory effects of quercetin (Q), kaempferol (K) and taxifolin (T) in J774A |
Significantly inhibited the expression of the xenobiotic metabolizing enzyme, cytochrome p450 1B1 (CYP1B1), with potency of inhibition ranked K > Q ≫ T |
K exhibited most potent anti-inflammatory effects, and possessed the most potent inhibitory effect on CYP1B1 expression. The anti-inflammatory efficacy of a compound is negatively related to CYP1B1 expression |
75
|
| Flaxseed |
Effects on different enzymes involved in the oestrogen pathway |
Significantly decreased the expression of CYP1B1 in ovaries |
Reduced the inflammatory and pro-carcinogenic micro-environment of the ovaries |
76
|
| Green tea extracts (GTE) |
Effect of GTE supplementation on upregulation of CYP1B1 mRNA in liver cells |
GTE supplementation significantly upregulated in CYP1B1 mRNA |
Liver samples exhibited potential modulation of its activity in response to GTE diet supplementation, indicating potential for higher toxicant degradation and clearance |
77
|
| Indole-3-carbinol (I3C) |
Effects on adipogenesis and angiogenesis-associated factors in mature adipocytes |
Significantly inhibited triglyceride accumulation in mature adipocytes in association with significantly increased expression of AhR and CYP1B1 proteins |
I3C is a potential therapeutic agent for treating obesity and obesity-associated disorders |
78
|
| Olive oil |
Preventative effects of olive oil on enzo(a)pyrene [B(a)P]-induced colon carcinogenesis |
Significantly altered the expression of drug-metabolizing enzymes (CYP1A1, CYP1B1) in both the colon and liver tissues |
Olive oil has a protective effect against environmental toxicant B(a)P-induced colon tumors by controlling the levels of CYP1A1, CYP1B1 |
79
|
| Folic acid |
Effect of folic acid (FA) on prevention of cardiac defects during embryo development of zebra fish |
Significantly prevented cardiac defects during embryo development by interfering with AhR and Wnt/b-catenin signaling pathways |
FA supplementation attenuated the extractable organic matter (EOM)-induced upregulation of AhR and its target genes including Cyp1a1, Cyp1b1, Ahrra, and Ahrrb |
80
|
| Piceatannol |
Effects of piceatannol against oxidative stress induced cell damage in neuroblastoma cells |
CYP1B1 plays a significant role in the conversion of resveratrol to piceatannol (3,5,3′,4′-tetrahydroxystilbene) |
Piceatannol stimulates BDNF (brain-derived neurotrophic factor), which is involved in neurite outgrowth and maintenance of function in neuronal cells piceatannol promotes cell survival by sustaining level of sirtuin 1 and seladin-1 mRNA on constant level |
81
|
| Apigenin, luteolin, scutellarein, kaempferol and quercetin |
Antiproliferative effect of the hydroxylated flavonoids apigenin, luteolin, scutellarein, kaempferol and quercetin in CYP1 combinant enzymes and in the CYP1 expressing cell lines MCF7 and MDA-MB-468, respectively |
CYP1 enzymes converted apigenin to luteolin and scutellarein, and kaempferol was metabolized only to quercetin. CYP1B1 metabolized luteolin to 6 hydroxyluteolin |
Molecular modeling demonstrated that CYP1B1 favored the A ring orientation of apigenin and luteolin to the heme group. The metabolism of hydroxylated flavonoids by cytochrome P450 CYP1 enzymes, notably CYP1A1 and CYP1B1, can enhance their antiproliferative activity in breast cancer cells |
82
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