Table 1.
Correlation between MMR genes and clinical characteristics in human cancer
| Gene name | Gene Position | Tumor type | Related characteristics |
|---|---|---|---|
| MSH2 | 2p21-p16.3 | Colorectal Cancer; NSCLC; Thyroid Cancer; Breast Cancer; Liver Cancer; et al. | Overall survival; Drug resistance |
| MSH3 | 5q14.1 | Colorectal Cancer; Prostate Cancer; Breast Cancer; Thyroid Cancer; Prostate Cancer; Esophageal Cancer; Liver Cancer; et al. | Overall survival; Cancer risk; Chemotherapy resistance (Cisplatin, PARPi et al.) |
| MSH4 | 1p31.1 | Head and neck Cancer; Thyroid Cancer; et al. | Anti PDL1 treatment; Overall survival |
| MSH5 | 6p21.33 | Lung Cancer, non-Hodgkin's lymphoma | Cancer risk |
| MSH6 | 2p16.3 | Colorectal Cancer; Prostate Cancer; Breast Cancer; Thyroid Cancer; Prostate Cancer; Esophageal Cancer; Pancreatic Cancer; Liver Cancer; et al. | Overall survival; Cancer risk; Chemotherapy resistance; Radiotherapy resistance; Immunotherapy; |
| MLH1 | 3p22.2 | Colon Cancer; Gallbladder Cancer; Lung Cancer; Breast Cancer; Pancreatic Cancer; et al. | Metastasis; Overall survival; Chemotherapy resistance (TKI drug, PARPi et al.); Radiotherapy resistance; Immunotherapy |
| MLH3 | 14q24.3 | Endometrial Cancer. Colorectal Cancer; Liver Cancer. | Overall survival; Cancer risk; |
| PMS2 | 7p22.1 | Colorectal Cancer; Prostate; Breast Cancer; Thyroid Cancer; prostate Cancer; Esophageal Cancer; Pancreatic Cancer; Liver Cancer; et al. | Metastasis; Overall survival; Chemotherapy resistance; Radiotherapy resistance; Immunotherapy |
| PMS1 | 2q32.2 | Colon Cancer; Breast Cancer; et al. | DNA repair; Cancer risk |