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Mitophagy inhibition could impair the regulatory effect of UCP1 on metastasis and invasion of TNBC. (A) Expression of PINK-1 in MDA-MB-231and (B) BT549 with UCP1 overexpressed after 5μM and 10μM CsA treated. (C) Transwell assay of MDA-MB-231 and (D) BT549 in groups same as (A) and (B). (E) Transwell assay (with matrix) of MDA-MB-231 and (F) BT549 in groups as indicated. (G) Protein expression of regulated factors of invasion on MDA-MB-231 and (H) BT549 in groups as indicated.
