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. 2022 Apr 18;18(7):2949–2961. doi: 10.7150/ijbs.68438

Figure 5.

Figure 5

Inactivation of caspase-3 and GSDME reversed the regulatory effect of UCP1 on the proliferation of TNBC. (A) Expression of GSDME and caspase-3 with active subunits in MDA-MB-231 and (B) BT549 with UCP1 stable transfected, meanwhile after 60μM Z-DEVD-Fmk treated. (C) The cell cycle of MDA-MB-231 and (D) BT549 in groups same as (A) and (B). (E) CCK8 assay of MDA-MB-231 and (F) BT549 in groups as indicated. (G) Western blot of regulated factors of cell cycle and proliferation on MDA-MB-231 and (H) BT549 with UCP1 stable transfected after 60μM Z-DEVD-Fmk treatment. **: p<0.01, ***: p<0.001.