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. 2022 Apr 11;18(7):2867–2881. doi: 10.7150/ijbs.66854

Figure 1.

Figure 1

SNAIL-dominated EMT and CXCL2-dominated macrophage infiltration are important features of lung metastases. (A) Colorectal carcinoma in situ and lung metastases heatmap of the 30 DEGs with |log2fold change | > 2, P < .05. Red: higher expression; blue: lower expression. (B) Colorectal carcinoma in situ and lung metastases module-trait associations. Each row corresponds to a module eigengene, and each column corresponds to a trait. Each cell contains the corresponding correlation and p value. The table is colour-coded by correlation according to the colour legend. (C) A scatter plot of gene significance (GS) and module members (MM) of relapses in the SteelBlue module. (D) Modular analysis of PPI networks in lung metastases. (E) Module analysis and statistical node number of the PPI network of lung metastatic tumours. (F) Pathways enriched by lung metastases, including the Intestinal Immune Network For IGA Production, Cytokine Receptor Interaction, Chemokine Signalling Pathway, and JAK STAT Signalling Pathway. (G) Heatmap of immune cell infiltration in lung metastases versus primary tumours. (H) Violin diagram of immune cell infiltration in lung metastases versus primary tumours.