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. Author manuscript; available in PMC: 2022 May 3.
Published in final edited form as: Oncogene. 2022 Jan 20;41(8):1129–1139. doi: 10.1038/s41388-021-02154-0

Figure 2. BAP1 mutant UM cells have elevated PDHK1-PDH phosphorylation.

Figure 2.

a. Average expression of PDH (E1), DLAT (E2) and PDHK1 between BAP1 wild type (92.1, OMM1.3, UM001, UM004, UM002B and MM66) and mutant (MP46, MP65, MP38, MM28, PDX4 and WM3618F) UM cells were analyzed by RPPA analysis. RPPA data were used to determine antibodies that are significantly different between mutant and wild-type cell lines. Comparison of average normalized log2 values were performed by the two-sample t-test method and assumed unequal variance. Data points are shown as individual lysate collections **p<0.01. b. Validation of protein expression by Western blot.