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CuI down-regulated JA2/STAT3 signalling pathway in PDAC cells. (A) CuI induced a decrease of p-JAK2 and p-STAT3 protein levels and does not influence the protein levels of T-JAK2 and T-STAT3 in CuI-treated PDAC cells. (B) Colivelin activated JAK2/STAT3 signalling pathway inhibited by CuI. (C-D) Colivelin significantly rescued the number of clones inhibited by CuI. (E) Colivelin significantly restored the number of cells inhibited by CuI.
