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. 2022 Feb 22;10(2):e003978. doi: 10.1136/jitc-2021-003978

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Enhancement of CD8 T cell responses by help provided by CD4 T cells. HHD-DR1 mice (n=4 mice/peptide) were immunized with CD8 neoAg epitope KYV and poly(I:C), in combination with CD4 neoAg epitope EVT, antiCD40 antibodies or both. Responses against KYV (A) and EVT (B) were measured by Elispot. Results correspond to a representative experiment out of two carried out independently. Equivalent immunization experiments (n=4 mice/group) were carried out using other epitope combinations, sharing either the CD8 (C) or the CD4 (D) epitopes used in panels A, B. * p<0.05; ** p<0.01; *** p<0.001. NT, not tested.