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. 2022 Feb 22;10(2):e003978. doi: 10.1136/jitc-2021-003978

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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In vitro induction of human CD8 T cell responses against neoAgs in healthy donors. CD8 T cells form HLA-A*02.01 healthy donors were stimulated in vitro with monocyte-derived dendritic cells pulsed with neoAg CD8 epitope peptides KYV (A) or ALL (B) and expanded. (A, B) Dot plots showing IFN-γ production of in vitro primed CD8 +T cells after mutant or WT peptide-specific restimulation on day 21 (gated on bulk CD8 +T cells). Frequencies of IFN-γ+ cells within the CD8 +T cell population after subtracting values obtained in the absence of peptide restimulation are depicted. (C) Proportions of healthy donors showing an IFN-γ production after restimulation with the mutant peptides are depicted, respectively. Numbers of analyzed healthy donors are indicated.