Effects of ACCE and reference drugs (clonidine and yohimbine) on gastrointestinal motility in rata.
| Rat-groups | Total small intestine length (cm) | GI-motility | ||
|---|---|---|---|---|
| Transit distance of charcoal meal (cm) | GI-charcoal transit (%) | Acceleration/inhibition (%) | ||
| Control (10 mL kg−1) | 83.65 ± 5.66 | 66.25 ± 3.18 | 79.20 ± 3.04 | — |
| Clonidine (1 mg kg−1) | 77.27 ± 4.11 | 30.12 ± 2.77* | 39.00 ± 2.47* | 54.53 |
| Yohimbine (2 mg kg−1) | 86.27 ± 5.02 | 86.03 ± 4.21* | 99.72 ± 2.38* | 30.00 |
| Aqueous extract (ACCE) 150 mg kg−1 | 87.40 ± 3.68 | 75.21 ± 2.56#* | 86.05 ± 4.34#* | 14.00 |
| 300 mg kg−1 | 86.45 ± 3.17 | 82.37 ± 2.162#* | 95.28 ± 3.16#* | 24.33 |
a
ACCE/drugs modulations reflected by indicated parameters and assessed in healthy and treated rats. Data are expressed as mean ± standard error (n = 7); *p < 0.05 versus control group, #p < 0.05 versus yohimbine/clonidine-groups.