Table 5.
Kaplan-Meier analysis of the probability of improvement in IBD symptoms in relation to with H. pylori infection and IBD treatment strategy
| Variable | Group | Case summary | No of events N (%) | Censored N (%) | Event time (bimonthly visit) |
No of events (recovery*) | No of relapse | No at risk (to recovery*) | Probability of recovering* | Test of equality of recovery* | ||
| Log rank (Mantel-Cox) | Breslow (generalised Wilcoxon) | Tarone-Ware | ||||||||||
| P value | ||||||||||||
| H. pylori infection in patients with IBD | Negative | n=92 | 73 (79.3) | 19 (20.7) | 1 | 0 | 2 | 92 | 0.000 | 0.969 | 0.708 | 0.833 |
| 2 | 1 | 4 | 91 | 0.011 | ||||||||
| 3 | 0 | 5 | 91 | 0.011 | ||||||||
| 4 | 14 | 3 | 77 | 0.163 | ||||||||
| 5 | 17 | 1 | 60 | 0.348 | ||||||||
| 6 | 41 | 4 | 19 | 0.793 | ||||||||
| Positive | n=90 | 70 (77.8) | 20 (22.2) | 1 | 0 | 0 | 90 | 0.000 | ||||
| 2 | 0 | 3 | 90 | 0.000 | ||||||||
| 3 | 2 | 1 | 88 | 0.022 | ||||||||
| 4 | 22 | 6 | 66 | 0.267 | ||||||||
| 5 | 8 | 6 | 58 | 0.356 | ||||||||
| 6 | 38 | 4 | 20 | 0.778 | ||||||||
| Treatment of IBD | Conventional | n=106 | 86 (81.1) | 20 (18.9) | 1 | 0 | 0 | 106 | 0.000 | 0.893 | 0.867 | 0.880 |
| 2 | 0 | 3 | 106 | 0.000 | ||||||||
| 3 | 2 | 1 | 104 | 0.019 | ||||||||
| 4 | 21 | 5 | 83 | 0.217 | ||||||||
| 5 | 16 | 6 | 67 | 0.368 | ||||||||
| 6 | 47 | 5 | 20 | 0.811 | ||||||||
| Biological | n=76 | 57 (75.0) | 19 (25.0) | 1 | 0 | 2 | 76 | 0.000 | ||||
| 2 | 1 | 4 | 75 | 0.013 | ||||||||
| 3 | 0 | 5 | 75 | 0.013 | ||||||||
| 4 | 15 | 4 | 60 | 0.211 | ||||||||
| 5 | 9 | 1 | 51 | 0.329 | ||||||||
| 6 | 32 | 3 | 19 | 0.750 | ||||||||
p value significate at<0.05.
*Recovery reflects a state of remission of IBD condition.
H. pylori, Helicobacter pylori; IBD, inflammatory bowel disease.