Table 3.

Overall survival analyses in stage I-IV ACC patients. P-values < 0.05 are indicated in bold.

	Univariate analysis			Multivariable analysis
	HR	95% CI	P-value	HR	95% CI	P-value
Age (per year increase)	1.01	0.99–1.04	0.40
Sex (M vs F)	0.51	0.21–1.23	0.13
Cortisol secretion (yes vs no)	4.04	1.62–10.07	0.003	1.16	0.32–4.13	0.82
ENSAT stage
III vs I–II	5.68	2.44–13.23	<10−4	8.19	2.41–27.81	0.0007
IV vs I–II	10.95	4.35–27.54	<10−6	32.34	7.03–148.86	<10−5
Resection status (R1–R2–RX vs R0)	4.88	2.39–9.98	<10−4	0.97	0.35–2.66	0.95
Ki-67 proliferation index
10–19 % vs <10%	2.96	0.66–13.27	0.16	0.81	0.15–4.28	0.80
≥20% vs <10%	10.20	3.05–34.12	0.0002	1.79	0.35–9.00	0.48
Molecular class (C1A vs C1B)	10.15	3.09–33.35	0.0001	7.5	1.47–38.13	0.01