Fig. 7. Effects of milk oxidation diet on the relative expression of hippocampus genes and proteins in SD rats. (A) The relative mRNA expression of Nrf2, Prdx-1, P38-α; (B) the relative mRNA expression of CytC, caspase-3, caspase-9; (C) the relative mRNA expression of Nr1, Nr2a, Nr2b, CaMK2A, CaMK2B; (D) the relative mRNA expression of CREB, BDNF, Trkb, PSD-95; (E) Western blot bands of Bax, Bcl-2, and β-actin; (F) relative expression of Bax protein; (G) relative expression of Bcl-2 protein. Nrf2, nuclear factor (erythroid-derived 2)-like 2; Prdx-1, peroxiredoxin-1; P38-α, mitogen-activated protein kinase 14; CytC, cytochrome complex; caspase-3, cysteine-requiring aspartate protease-3; caspase-9, cysteine-requiring aspartate protease-9; Nr1, N-methyl-d-aspartate receptor 1; Nr2a, N-methyl-d-aspartate receptor 2a; Nr2b, N-methyl-d-aspartate receptor 2b; CAMK2A, Ca²⁺/calmodulin-dependent protein kinase II alpha chain; CAMK2B, Ca²⁺/calmodulin-dependent protein kinase II beta chain; CREB, cAMP response element-binding protein; BDNF, brain-derived neurotrophic factor; PSD-95, postsynaptic density protein 95; Bcl-2, B-cell lymphoma 2; Bax, Bcl-2-associated X. SWM, 180 °C spray-dried whole milk group; FWM, freeze-dried whole milk group; FWM + LDT freeze-dried whole milk + low dityrosine group; FWM + HDT, freeze-dried whole milk + high dityrosine group. Data are expressed as the mean ± SEM (n = 10 rats per group). Means among bars without a common letter differ, P < 0.05.