Table 1.

Mechanism and roles of exosomal circular RNA in solid cancers

Circular RNA	Expression of circRNA	Tumor types	miRNA, RBP	Downstream pathways	Biological functions	References
CircRNA_100284	up	hepatocellular carcinoma	miR-217	EZH2 and CyclinD1	Cell proliferation	[52]
Circ-DB (has_circ_0025129)	up	hepatocellular carcinoma	miR-34a	USP7/Cyclin A2	Tumor growth and metastasis	[53]
CircPTGR1	up	hepatocellular carcinoma	miR-449a	MET	Disrupt tumor microenvironmental homeostasis and promote metastasis	[54]
Circ-0000284	up	cholangiocarcinoma	miR-637	LY6E	Proliferation, migration, invasion	[55]
Circ-PDE8A	up	pancreatic ductal adenocarcinoma	miR-338	MACC1/MET/ERK or AKT pathway	Invasive growth	[49]
Circ-IARS	up	pancreatic cancer	miR-122	RhoA activity/ F-actin/ ZO-1	Vascular endothelial permeability and tumor metastasis	[56]
Circ LONP2 (hsa_circ_0008558)	up	colorectal cancer	Promote pre-miR-17 mature	Recruit DGCR8 and Drosha complex	Invasion	[57]
Circ PRMT5	up	urothelial carcinoma of the bladder	miR-30c	SNAIL1/ E-cadherin pathway	Promote pathological EMT	[58]
Circ_0044516	up	prostate cancer	miR‐29a‐3p	-	Proliferation and metastasis	[59]
CiRS-133	up	gastric tumors	miR-133	PRDM16/UCP1 pathway	Cancer cachexia	[50]
Circ-0051443	down	hepatocellular carcinoma	miR-331-3p	BAK1	Promote apoptosis and blocking cell cycle	[60]
Circ-ABCC1	up	colorectal cancer	interact with β-catenin	Wnt/β‐catenin pathway	Cell stemness, sphere formation and metastasis	[61]
Circ-CCAC1	up	cholangiocarcinoma	interact with EZH2	SH3GL2/ ZO-1/Occludin	Accelerate CCA tumorigenesis and metastasis	[62]
Has-circ_0074854	up	hepatocellular carcinoma	interact with HuR	ZEB1 signaling pathway	Activate the polarization of M2 macrophage and promote EMT of HCC cells	[63]
CircFARSA	up	non-small cell lung cancer	interact with eIF4A3	PI3K/AKT signaling pathway	Mediate polarization of M2 macrophages and promote EMT	[64]
CircLPAR1	down	colorectal cancer	interact with eIF3h	METTL3-eIF3h/ BRD4	Inhibit the proliferation, invasion and migration of CRC	[65]

Not detection