Table 2.

Exosomal circRNA implicate in hematological malignancies

Diseases	Exosomal circRNA	Levels	miRNAs, RBPs, and pathways targeted	Impact on Hematologic disease	References
AML	circ_0004136	up	miR-570-3p/TSPAN3	Increase AML cell viability, cell cycle progression, migration and invasion and decreased apoptosis	[94]
AML	circ_0009910	up	miR‐5195‐3p/GRB10	Increase proliferation, apoptosis and cell cycle progression of AML cells	[95]
CLL	mc-COX2	up	-	Dampen mitochondrial functions and regulates CLL cell growth	[96]
MM	circMYC	up	-	Associate with the recurrence and Bortezomib resistance	[97]
MM	chr2:2,744,228–2,744,407 +	up	hsa-miR-6829-3p/GRIN2B	Neuronal cell death and MM-related PN	[98]
MM	circ-G042080	up	hsa-miR-4268/TLR4	Associate with MM-related myocardial damage and increase autophagy level in cardiomyocytes	[99]

Not detection