Table 1.
Baseline characteristics of all patients
| IVIG (n = 92) | Acetaminophen (n = 93) | p | |||
|---|---|---|---|---|---|
| n/mean | %/SD | n/mean | %/SD | ||
| Female gender, n (%) | 31 | 33.7% | 23 | 24.7% | 0.18 |
| Age (yr) | 70.1 | 14.7 | 64.2 | 17.7 | 0.01 |
| Weight (kg) | 56.0 | 11.2 | 61.2 | 12.4 | < 0.01 |
| Comorbidities, n (%) | |||||
| Hypertension | 36 | 39.1% | 35 | 37.6% | 0.83 |
| Diabetes | 21 | 22.8% | 17 | 18.3% | 0.44 |
| Chronic heart failure | 7 | 7.6% | 18 | 19.4% | 0.02 |
| Infection site, n (%) | |||||
| Pneumonia | 33 | 35.9% | 21 | 22.6% | 0.05 |
| Bacteremia | 46 | 50.0% | 30 | 32.3% | 0.01 |
| Intra-abdominal | 26 | 28.3% | 20 | 21.5% | 0.29 |
| SOFA score (median/quartile) | 8 | (11–14) | 4 | (6–8) | < 0.01 |
| Organ support, n (%) | |||||
| Invasive mechanical ventilation | 68 | 73.9% | 55 | 59.1% | 0.03 |
| Renal replacement therapy | 52 | 56.5% | 28 | 30.1% | < 0.01 |
| Vasopressors | 65 | 70.7% | 18 | 19.4% | < 0.01 |
| Drugs, n (%) | |||||
| Diuretics | 6 | 6.5% | 18 | 19.4% | < 0.01 |
| Nicardipine | 5 | 5.4% | 10 | 10.7% | 0.19 |
| Plasma creatinine (mg/dL) | 1.95 | 1.44 | 1.64 | 1.82 | 0.21 |
| Vital sign at IVIG/acetaminophen infusion | |||||
| SBP (mmHg) | 109.0 | 27.0 | 128.8 | 28.2 | < 0.01 |
| MAP (mmHg) | 74.6 | 18.4 | 82.6 | 17.0 | < 0.01 |
| DBP (mmHg) | 55.6 | 15.1 | 59.6 | 14.1 | 0.06 |
| HR (beats/min) | 101.1 | 20.8 | 101.9 | 22.2 | 0.79 |
IVIG intravenous immunoglobulin, SOFA sequential organ failure assessment, SBP systolic blood pressure, MAP mean arterial pressure, DBP diastolic blood pressure, HR heart rate, SD standard deviation