Table 2.

Summary of genomic studies done in mouse microvascular endothelial cells investigating differential gene expression after inflammatory/septic-like stimulation. Gene definitions can be found in Supplementary Table 2.

Reference	Methodology	Region	KEGG pathway hits		GO pathway hits		Genes
			Upregulated	Downregulated	Upregulated	Downregulated	Upregulated	Downregulated
(54)	Embryonic stem cells were differentiated into organ-specific ECs
		AT	Osteoclast differentiation, MAPK signaling, metabolism				Csf2rb, Cldn15, Acox1, da, Papss2
		Brain	ErbB signaling, RPAR signaling, MAPK signaling				Slco1c1, Slco1a4, Slc22a8, Mfsd2a, Stra6
		Diaphragm	Toxoplasmosis, RIG-I-like signaling, apoptosis				Gm12216, Adamts4, Sphk1, Prkcc
		heart	Focal adhesion, axon guidance signaling, ECM–receptor interaction				Ccnd1, Ctnnbip1, Plcb4, Myadm, Slc28a2
		Kidney	Endocytosis, hematopoietic cell lineage, calcium signaling
		Liver	TGF-B signaling, complement and coagulation, hematopoietic cell lineage				Clec4g, Fcgr2b, Stab2, Mrc1, Plxnc1, Apc, Lrp6, Ep300
		Lung	Neuroactive ligand-receptor interaction, WnT signaling, metabolism				Tmem100, Scn7a, Adrb1, Daam1, Nkd1
		MG	JAK-STAT, NOD-like receptor signaling, MAPK signaling				Emp1 Atf4, Dusp5, Gadd45b, Myc, Relb
		Pancreas	Adherens junction, focal adhesion, MAPK signaling				Fgfr1, Ntf3, Pla2g1, Cele2a, Prss2
		SM	JAK-STAT, TLR signaling, metabolism				Csf1, Cxcl, Cxcl10, Cxcl2, Osmr
		Trachea	Gap junction, NOD-like receptor signaling, TLR signaling				Rgs16, Col13a1, Stc1, Psd, Nr4a2, Bhihe40
(50)	Cultured brain, lung and heart ECs were stimulated with LPS for 6 and 24 h
		Brain
		6 h			Leukocyte migration, response to LPS		Ccl11, Timp1, Tnfa, Il1a , I1b, Sele, Selp
		24h			Response to chemokine, cell chemotaxis, leukocyte/neutrophil migration		24 hours: Ccl3, Timp1, Ccl11, Selp, Sele
		Heart
		6 h			Cell chemotaxis, leukocyte migration		Ccl3, Sele, Selp, Cxcl55, Cxcl1, Il6, Cxcl3
		24 h			Leukocyte migration, neutrophil/leukocyte chemotaxis, response to chemokine		Cxcl5, Cxcl3, Selp, Sele, Acod1
		Lung
		6 h			Acute inflammatory response, cell chemotaxis		Cxcl1, Cxcl9, I1r2, Casp6, Il10, Ly96
		24 h			Cell chemotaxis, leukocyte/neutrophil chemotaxis, leukocyte migration		Mmp8, Il10, Acod1, Cxcl9
(51)	Mice were injected with LPS for 4 h prior to isolation of heart, brain liver and lung ECs	Kidney, brain, liver, lung, heart			Leukocyte migration, response to lipopolysaccharide, response to bacterium
		Brain					Sele, Selp, Icam1	Cdh5, Ctnna1, Cldn5, Thb, Vwf, Jam2
		Heart					Sele, Vcam1, Selp, Icam1, Serpine1	Cdh5, Ctnnb1, Ocln, Plau, Thbd
		Liver					Sele, Selp, Serpine1	Cdh5, Ctnnd11, Jam2, Jam3, Cldn5, Plat, Tfp1
		Lung					Sele, Vcam1, Selp, Serpine1
(52)	Mice were injected with LPS for 3 h prior to isolation of adrenal ECs	Adrenal			Innate immune response, inflammatory response, cellular response to LPS and Il1 activation	Activation of MAPK activity, Rho protein signal transduction, protein phosphorylation	Csf3, Ccl2, Cxcl10, Selp, Sele, Vcam1, Pdgf, Il6, Ifit2, Ifit3	Rapsn, Dsc2, Zc4gz, Kcbn1, Pcdh12, Kcnb1, Shh, Dapk2
(53)	Mice were injected with influenza infection for 6 h prior to isolation of lung ECs	Lung			Blood vessel development, positive regulation of cell motility, sprouting angiogenesis		Gpihbp1, Ifi47, Plvap, Sox17, Atf3, Nrp1, Nusap1, Birc5, Cdk1, Top2a, Kitl, Kdr, Atf3, Cd34
(55)	Cultured mouse brain ECs were stimulated with avian E.coli for 1–6 h	Brain	Ribosome, legionellosis, TNF signaling, HIF-1 signaling	Biosynthesis of amino acids, glycolysis		Nuclear part, intracellular part, intracellular organelle, cellular macromolecule metabolic process	Nectin3, Cxcl1, Cxcl2, Cxcl16, Ccl2, Ccrl2, C3ar1, Actb, Tlr4, Tlr13	Cdh5, Cdh24, Pcdh1, Pcdhgc3, Nectin1, Nectin2, Actn1