Table 3.

Summary of proteomic studies in mouse microvascular endothelial cells investigating differential protein expression after inflammatory/septic-like stimulation. Protein definitions can be found in Supplementary Table 3.

Reference	Methodology	Region	KEGG pathway hits		GO pathway hits		Proteins
			Upregulated	Downregulated	Upregulated	Downregulated	Upregulated	Downregulated
(56)	MRSA was injected in mice for 24 h before kidney, liver, heart, brain and white adipose tissue ECs isolation
		Liver	Cell adhesion molecules, Staphylococcus aureus infection		Leukocyte proliferation, cell–cell adhesion, positive regulation of cell death		SAA1, VCAM1, CXCL9, SAA1	HPGD, APOE, MUP3
		Brain			Cell–cell adhesion, neuron migration, axonogenesis		24 h: HP, ITIH4, CFB, CP, HPX
		Kidney	COVID-19, ECM-receptor interaction		Cell–cell adhesion, negative regulation of growth, cell morphogenesis		SAA1, SAA2, HP, FGB, ITIH3	RBP4, HDLBP
		Heart	COVID-19, PPAR signaling, hypertrophic cardiomyopathy		Skeletal tissue development, muscle contraction		SAA2, VCAM1, HP, ORM2, PDK4	TTR, C8, VCAN
		WAT			Collagen degradation, response to peptide hormone			LRPAP1, VCAN
(57)	Mice were injected with oleic acid for 6 h before lung ECs isolation	Lung	Complement and coagulation, ECM–receptor interaction, phagocytosis, amoebiasis		Immune system response, defense response, response to external stimulus		C1QA, C4BP, FGA, FGG, C4B, SERPINA6, C3, CFB	COL5A1, GNAI1, ATP8, MLST8, POSTN, TH, ST3GAL1, POLR2M
(58)	Mice were injected with LPS over 48 h before isolation of vascular beds
		Endothelial secretome	Metabolic pathways, endocytosis, biosynthesis of antibiotics, complement and coagulation, viral carcinogenesis, cell adhesion
		EC					SAA1, HX and HPX	CLU, AZGP1, C6, CFD, TLN1, GSN, F10
		Glycocalyx						APOB, C3, CFH, TLN1, C7, SPP2
		Vascular smooth muscle						GC, F12, C8, APOA4
(59)	Mice received a dose of cardiac radiation at 8 or 16 Gy before isolation of heart ECs
		8 Gy	EIF2 signaling, remodeling of epithelial adherens junction		Inflammatory response, cell assembly and organization, DNA repair/replication
		Heart					ICAM2, ITGB3, HSPA12b, THBS1, TUBA1A, TUBA4A, MCAM	VWF, ICAM1, LAMB, DLAT, NCL, VCP, FH1, HIST1HE, LMNB2
		16 Gy	EIF2 signaling, actin cytoskeleton signaling		Energy production, cell–cell signaling, cell movement
		Heart					CDH13, GDI2, LC25A4, DYNC1H1, CLTC	ACADM, ACTB, CALD1, DES, ECI1, MSN, PRKCDBP, TPM1
(60)	Mice were irradiated with a dose of 10 Gy at the thorax prior to the isolation of lung ECs	Lung	Metabolic pathways, endocytosis, pathways in cancer, PI3k–Akt signaling, cGas/STING-pathway				GBP2, ISG15, H2D1, SERPINB2, B2M, CASP7	FADS1, GBE1, DNPH1, MLYCD, FAM120C, ALDOC
(61)	Bile duct ligation was performed in mice prior to isolation of CD31-pulmonary cells		Secretion of chemokine and cytokine, Regulation of cell adhesion and migration, Complement and Coagulation		Secretion of chemokine and cytokine, Regulation of cell adhesion and migration, Complement and Coagulation		Lung: SERPINB1A, ANXA1, S100A9
(62)	Cultured mouse brain microvascular ECs were infected with herpes simplex virus for 24 h	Brain	NF-kB signaling, IL-17 signaling, NOD-like receptor signaling, TNF signaling, cell adhesion		Defense response, immune system response, response to biotic stimulus		VCAM1, JAMA, PDl1, CJUN, CCL2, CCL5, CXCR5, CCL2	TPST1, SNRPC, COBL, MMP15, CD9, BRD3, LRIG1