Table 2.
Differentially methylated regions associated with maternal early-pregnancy serum ferritin concentrations*
| DMR | CpGs | Effect | SE | p value | Nearest genes | Gene Group |
|---|---|---|---|---|---|---|
| chr 3: 138,725,153–138,725,311 | cg02806645 | − 2.7 × 10−3 | 4.4 × 10−4 | 4.0 × 10−10 | PRR23A |
TSS200 TSS1500 |
| cg06322988 | ||||||
| cg01926813 | ||||||
| cg07452777 | ||||||
| cg03772909 | ||||||
| chr 16: 2,902,921–2,903,392 | cg06186790 | − 2.2 × 10−3 | 3.9 × 10−4 | 1.7 × 10−8 | PRSS22 |
3'UTR Body |
| cg16701914 | ||||||
| cg06077305 | ||||||
| cg04468817 |
Chr, Chromosome; DMR, differentially methylated region; TSS, transcription start site; UTR, untranslated region; SE, standard error
*DMRs were identified from the results of the meta-analysis of epigenome-wide association study results of maternal early-pregnancy serum ferritin concentrations and DNA methylation in cord blood for individual CpGs, which used results from robust linear regression models that were adjusted for gestational age at serum measurement, maternal age at intake, educational level, pre-pregnancy body mass index, smoking, child sex, cell-type proportions, and batch (model 3)