Table 3.
Look-up of three CpGs identified in cord blood in meta-analysis of epigenome-wide association study results of maternal early-pregnancy serum ferritin concentrations and DNA methylation in older children
| CpG | Chr | Position | Gene | Effect | SE | p value | I2 |
|---|---|---|---|---|---|---|---|
| a. Early childhood | |||||||
| cg02806645 | 3 | 138,725,153 | PRR23A | − 1.9 × 10–4 | 5.8 × 10–5 | 7.3 × 10–4 | 0 |
| cg06322988 | 3 | 138,725,189 | PRR23A | − 9.7 × 10–5 | 3.0 × 10–5 | 1.4 × 10–3 | 0 |
| cg04468817 | 16 | 2,903,392 | PRSS22 | − 8.4 × 10–5 | 4.1 × 10–5 | 3.8 × 10–2 | 0 |
| b. Late childhood | |||||||
| cg02806645 | 3 | 138,725,153 | PRR23A | − 2.8 × 10–4 | 6.3 × 10–5 | 9.7 × 10–6 | 0 |
| cg06322988 | 3 | 138,725,189 | PRR23A | − 5.7 × 10–5 | 2.8 × 10–5 | 4.2 × 10–2 | 77 |
| cg04468817 | 16 | 2,903,392 | PRSS22 | − 1.2 × 10–4 | 4.0 × 10–5 | 2.2 × 10–3 | 0 |
Chr, Chromosome; SE, standard error; I2, I-square
Effect estimates represent the difference in DNA methylation per 1 µg/L increase in maternal early-pregnancy serum ferritin concentrations. The model was adjusted for gestational age at serum ferritin measurement, maternal age at intake, educational level, pre-pregnancy body mass index, smoking, child sex, child age, cell-type proportions, and batch