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The pathophysiology of exon 14 alterations. a) the MET structure. b) the impact of MET exon 14 alterations and development of exon 14 skipping. c) selected MET exon 14 alterations and the consequent lack of CBL binding, decreasing the MET polyubiniquitation and degradation
HGF: hepatocyte growth factor, CBL: Casitas B-lineage lymphoma, WT: wild-type, Δexon 14: exon 14 skipping.
