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. 2022 May 4;12(9):2048–2074. doi: 10.1007/s13346-022-01147-0

Fig. 1.

Fig. 1

The pre-clinical assessment cascade for assessing NBM safety and efficacy. Following pre-screening and sterility assessment, a candidate NBM passes through physicochemical characterization, in vitro and in vivo experiments, before being deemed safe to enter human clinical trials