TABLE 2.

Susceptibilities of S. pneumoniae isolates according to the presence or absence of erm(B) and mef(A) erythromycin resistance genes

MLS resistance genotype (no. of isolates) and antibiotic	MIC (μg/ml)a
	Range	50%	90%	Geometric mean
erm(B) and mef(A) negative (125)
Penicillin	0.008–4	0.03	1	0.06
Cefotaxime	0.004–1	0.01	0.25	0.02
Telithromycin	0.002–0.06	0.01	0.06	0.01
Erythromycin	0.008–2	0.03	0.06	0.02
Clindamycin	0.008–0.12	0.03	0.06	0.03
Quinupristin-dalfopristin	0.06–4	1	2	0.9
Levofloxacin	0.12–1	1	1	0.65
erm(B) positive and mef(A) negative (73)
Penicillin	0.01–4	0.5	2	0.45
Cefotaxime	0.008–1	0.25	1	0.15
Telithromycin	0.004–1	0.03	0.12	0.03
Erythromycin	0.5–>64	>64	>64	45.0
Clindamycin	0.06–>64	64	>64	18.7
Quinupristin-dalfopristin	0.25–8	1	2	0.90
Levofloxacin	0.25–8	0.5	1	0.57
erm(B) negative and mef(A) positive (4)
Penicillin	0.03–2			0.17
Cefotaxime	0.008–0.25			0.06
Telithromycin	0.01–0.5			0.09
Erythromycin	0.5–8			2.82
Clindamycin	0.03–0.06			0.04
Quinupristin-dalfopristin	1–2			1.68
Levofloxacin	0.25–2			0.84
erm(B) and mef(A) positive (1)
Penicillin	0.5
Cefotaxime	0.12
Telithromycin	0.06
Erythromycin	64
Clindamycin	>64
Quinupristin-dalfopristin	2
Levofloxacin	1

^a50% and 90%, MICs at which 50 and 90% of isolates are inhibited, respectively.