Binding parameters of selected natural polyphenols with PDK3.

S. No.	Compound	Chemical structure	ΔGa (kcal mol−1)	Binding affinityb (Ka) M−1
1.	Ellagic acid		−7.9	2.68 × 108
2.	Capsaicin		−6.6	3.69 × 106
3.	Ursolic acid		−7.6	5.67 × 105
4.	Limonin		−7.7	3.16 × 107
5.	Vanillin		−6.0	1.78 × 105
6.	Citral		−6.6	5.66 × 106
7.	dl-α-Tocopherol acetate		−7.4	4.32 × 106
8.	Simvastatin		−7.2	3.86 × 105

^aFree energy calculated from docking analysis.

^bBinding affinity (K_a) calculated from fluorescence analysis.