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. Author manuscript; available in PMC: 2022 May 4.
Published in final edited form as: J Am Chem Soc. 2020 Aug 27;142(36):15259–15264. doi: 10.1021/jacs.0c07700

Figure 1.

Figure 1.

Structures of fluorescent trehalose derivatives and the proposed labeling of Mtb phagocytosed within macrophages. CDG-Tre probes are taken up by macrophages into phagosomes, then reach the periplasmic layer of Mtb cells. [Inset] The probes are activated by BlaC and processed by Ag85 enzymes into 6-TG-Tre monomycolate (6-TG-Tre-MM) with a mycolate chain transferred from another molecule of trehalose monomycolate (TMM). 6-TG-Tre-MM was further incorporated into the outer leaflet of the capsule.