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. Author manuscript; available in PMC: 2022 May 4.
Published in final edited form as: Trends Mol Med. 2020 Sep 15;26(10):913–923. doi: 10.1016/j.molmed.2020.07.004

Figure 2. Ingenuity Pathway Gene Network Analysis of the Procathepsin D-Prosaposin-Progranulin Network (PPPN) and Related Genes.

Figure 2.

This analysis covers the PPPN genes (blue), SNCA and GBA1 (orange), and related receptors (lavender). The intermediate genes are illustrated in white. The direct (unbroken arrows) and indirect (dashes) relationships between the genes are shown. The results show an effect of GBA1 and PSAP on glucosylceramides with different length carbon chains. Some miRNA that may directly affect the network are also shown. The different symbols shown in the legend indicate the function of many of the genes or proteins. This pathway analysis illustrates not only the effect of PPPN proteins on each other, but also their direct influence on SNCA degradation and GCase activity.