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. 2022 May 4;12:7300. doi: 10.1038/s41598-022-11229-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representative images of H and E-stained kidney sections from mice treated with a drug cocktail or control. (A) The control mouse kidney shows moderate to severe aging lesions (scored as a grade 3). Specific lesions include moderate nephropathy characterized by multifocal tubular basophilia (yellow arrows), glomerular atrophy and dilated Bowman’s space (green arrows) and interstitial inflammatory infiltrates (blue arrows). (B) The cocktail treated mouse kidney shows fewer and less severe aging changes (scored as a grade 1), characterized by focal tubular basophilia (yellow arrows). Magnification ×200.