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. 2022 May 4;12:7300. doi: 10.1038/s41598-022-11229-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Performance tests were conducted in HET3 mice at 23 months of age, 3 months after being started on chow containing the drug cocktail or placebo. (A) Values for the box maze were standardized times in seconds to find the escape hole in trial 3. (B) Values for the rotarod were standardized times in seconds staying on the rotating rod. (C) Values for grip strength were standardized force in newtons per body weight measuring the ability to maintain forepaw grip from a parallel meter bar. N = 12–14. *P < 0.05; two-tailed, unpaired Student’s t-test.