Table 4A.

The TIMBER-K and TIMBER-N arms of the study were divided into treatment subgroups using the basal DSR plasma concentration of 3.5 μM. The arms were divided into “high” DSR subgroups (≥3.5 μM), TIMBER-K(H) and TIMBER-P(H) and “normal” DSR subgroups (< 3.5 μM), TIMBER-K(N) and TIMBER-P(N). The effect of Ket on basal DSR plasma concentrations at the end of the Ket infusion (40 min DSR) was examined by the determination of the percent change (%) of DSR concentration in each subject.

Groups	Subject	Basal DSR (μM)	PCL Baseline	Response (days)	40 min DSR (μM)	Percent change (%)
TIMBER-K (H)	3	3.5	80	27	2.7	−21
	4	5.0	82	21	3.5	−30
	9	6.2	81	20	4.7	−25
Mean ± SD		4.9 ± 1.4	81.0 ± 1.0	22.7 ± 3.8	3.6 ± 1.0	25 ± 5
TIMBER-K (N)	1	3.2	76	71	2.8	−14
	16	3.3	70	55	2.4	−7
	18	1.4	78	48	1.3	−3
	20	1.6	67	29	1.5	−3
	13	2.6	75	25	3.1	+8
	17	3.0	67	14	2.6	−14
Mean ± SD		2.5 ± 0.8	72.2 ± 4.8	40.3 ± 21.3	2.3 ± 0.7	8 ± 6
TIMBER-P (H)	11	3.6	60	15	3.1	−14
	15	4.5	75	8	4.2	−5
	5	5.0	76	14	4.3	−14
	6	5.4	77	4	4.8	−11
	2	6.1	77	12	5.7	−7
Mean ± SD		4.9 ± 0.9	73.0 ± 7.3	10.6 ± 4.6	4.4 ± 0.9	10 ± 4
TIMBER-P (N)	19	1.5	76	21	1.3	−15
	12	1.6	66	4	1.4	−12
	10	2.3	62	28	1.9	−16
	14	2.3	75	18	2.2	−3
	7	3.2	60	41	2.7	−14
Mean ± SD		2.2 ± 0.7	67.8 ± 7.4	22.4 ± 13.9	1.9 ± 0.6	12 ± 5