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. 2022 May 4;18(5):e10630. doi: 10.15252/msb.202110630

Figure 3. Growth‐lag model reproduces monoculture growth dynamics.

Figure 3

  1. A simple model of growth and lag phases. (i) Species initially grow exponentially with Aci2 initially consumes only alanine and Pa consuming alanine and glutamate in a fixed 2:3 ratio. (ii) When a resource is depleted, both species experience a diauxic lag. Aci2’s lag time is long and varies with resource supply. Pa’s lag is short and constant at 1 h. Growth rates recover with a quadratic time dependence. (iii) Once recovered from its diauxic lag, each species grows on the remaining resource at its initial growth rate. (Modeling details in Materials and Methods.)
  2. Model predictions for Aci2’s monoculture growth for different resource supply ratios when started at a 104 dilution from carrying capacity. Each row of pixels is the calculation for a separate condition.
  3. The equivalent predictions for Pa’s growth.
  4. Comparison of the monoculture growth calculations at 8:1, 1:1, and 1:8 resource supply ratios. The appearance of initial lag is due to the growth that needs to happen before population sizes become significant on a linear scale. Population sizes are presented in dimensionless units (Materials and Methods).