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. 2022 May 4;17(5):e0266980. doi: 10.1371/journal.pone.0266980

Fig 5. In vitro activity of BOXR1030 under conditions simulating the solid tumor microenvironment.

Fig 5

BOXR1030 or control CAR T cells were repeat stimulated with GPC3+ target cell lines on day 0 and on day 3 in hypoxic conditions (A) or low glucose conditions (B). (A and B) The gMFI of CellTrace Violet (CTV) was measured for BOXR1030 and control CAR stimulated with target cells on day 7 in the indicated culture conditions and proliferation was plotted as 1/gMFI. (n = 5 for JHH7 stimulated conditions and n = 11 for Hep3B stimulated conditions, statistical analysis was performed using a 2-tailed paired t-test, and p-values <0.05 were considered statistically significant).