Fig 10. Serial reversal, cohort B.

(A) Day factor, (B) Sex factor and (C) Run factor comparisons of area under the curve (AUC) for activity curves of individual animals by sex, program day, and Run, separated by visit categories (Correct, SR-C or Opposite, SR-O). (D) Activity curves showing the fractional accumulation (y-axis) of correct visits or opposite visits over drinking session time (x-axis), reset every 180 minutes, by sex and Run. (E) For Run-1, 12 male and 10 female rats were tested since 2 females died just before the timeline started. Two males were excluded from the analysis of day 1, three males were excluded from the analysis of day 2, and four males were excluded from the analysis of days 3 and 4 during Run-1. These animals were excluded because they visited corners less than 25 times during the drinking session. For Run-2, 10 male and 10 female rats were tested, since one male died during the time between Runs and one male died after place learning with corner switch. All 20 rats were included in the analysis of Run-2. All data represented as mean ± SEM (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). See Tables 16 and 17 for statistical analysis. Males (M or ♂) are colored as red (Run-1) and light red (Run-2). Females (F or ♀) are colored as blue (Run-1) or light blue (Run-2).