Table 12. Statistical analysis of data shown in Fig 8A and 8B for behavioral sequencing, cohort B, Run-1, and Run-2.

Fig 8A and 8B	Mixed-effects analysis
Correct Run-1	Source of Variation	F (DFn, DFd)	P
	Interaction	F (4, 73) = 1.712	0.1565
	Day factor(8A)	F (4, 73) = 6.442	0.0002
	Sex factor(8B)	F (1, 20) = 2.837	0.1077
	post-hoc Sidak’s multiple comp. test	Summary	Adjusted P
	Male, day 1 vs. day 4	**	0.0013
	Male, day 1 vs. day 5	***	0.0003
	Male, day 2 vs. day 4	*	0.0367
	Male, day 2 vs. day 5	*	0.0102
Correct Run-2	Source of Variation	F (DFn, DFd)	P
	Interaction	F (4, 72) = 30.28	<0.0001
	Day factor(8A)	F (4, 72) = 43.82	<0.0001
	Sex factor(8B)	F (1, 18) = 76.20	<0.0001
	post-hoc Sidak’s multiple comp. test	Summary	Adjusted P
	Male, day 1 vs. day 2	****	<0.0001
	Male, day 1 vs. day 3	****	<0.0001
	Male, day 1 vs. day 4	****	<0.0001
	Male, day 1 vs. day 5	****	<0.0001
	Male, day 2 vs. day 3	****	<0.0001
	Male, day 2 vs. day 4	****	<0.0001
	Male, day 2 vs. day 5	****	<0.0001
	Female vs. Male, day 2	****	<0.0001
	Female vs. Male, day 3	****	<0.0001
	Female vs. Male, day 4	****	<0.0001
	Female vs. Male, day 5	****	<0.0001
Opposite Run-1	Source of Variation	F (DFn, DFd)	P
	Interaction	F (4, 73) = 0.5797	0.6783
	Day factor(8A)	F (4, 73) = 0.5545	0.6963
	Sex factor(8B)	F (1, 20) = 0.0003232	0.9858
Opposite Run-2	Source of Variation	Summary	Adjusted P
	Interaction	F (4, 72) = 3.377	0.0137
	Day factor(8A)	F (4, 72) = 12.53	<0.0001
	Sex factor(8B)	F (1, 18) = 0.5148	0.4823
	post-hoc Sidak’s multiple comp. test	Summary	Adjusted P
	Male, day 1 vs. day 2	*	0.0490
	Male, day 1 vs. day 3	**	0.0016
	Male, day 1 vs. day 4	****	<0.0001
	Male, day 1 vs. day 5	****	<0.0001
	Male, day 2 vs. day 5	**	0.0025

A p-value less than 0.05 is considered significant (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). ns not shown.