TABLE 3.

Effects of medium pH on antibacterial activity of TAK-083, amoxicillin, and clarithromycin against 29 clinical isolates of H. pylori

Compound pH	MIC (μg/ml)
	Range	MIC50a	MIC90b
TAK-083
4.5	≤0.008–0.063	0.016	0.031
5.5	≤0.008–0.031	0.016	0.031
6.5	≤0.008–0.031	0.016	0.031
7.5	≤0.008–0.016	0.016	0.016
Amoxicillin
4.5	0.031–1	0.125	0.5
5.5	0.016–1	0.063	0.25
6.5	≤0.008–0.5	0.031	0.25
7.5	≤0.085–0.5	0.031	0.25
Clarithromycin
4.5	0.125–>128	1	>128
5.5	0.125–>128	0.5	128
6.5	0.016–64	0.063	16
7.5	≤0.008–8	0.016	4

^aMIC required to inhibit 50% of strains. 

^bMIC required to inhibit 90% of strains.